We evaluated serum CA-125 levels in 122 patients with adnexal prospectively. The serum CA0125 levels were measured by immunoradiometric assay before laparotomy in 92 cases of benign cvarian tumor, 20 cases of mahgnant ovarian tumor, and 10 cases
of
pelvic abscess.
In normal control sixty-six apparently healthy women, the mean concentration of serum CA-125 level was 19.2U/ml and false positive rate at cut-off limits 35U/ml and 65U/ml were 10.6% and 0%.
The mean concentrations of preoperative surum CA-125 antigen in benign, malignant ovarian tumor and pelvic abscess were 32.8U/ml. 267.1U/ml, and 218U/ml respectively.
Among 91 patients with benign ovarian tumor, CA-125 levels above 35, and 65U/ml were detected in 23(25%), and 9(10.9%) cases of the patients respectively, Fifteen(75%) 0f 20 malignant ovarian tumors were associated with CA-125 levels above 35U/ml
and 11
of 20 cases(55%) had levels that exceeded 65U/ml. Among 10 patients with pelvic abscess, CA-125 levels greater than 35U/ml or 65U/ml were detected in 10 (100%) and nine (905) patients.
In 112 patients with benign and malignant ovarian tumors, the positive rates of preoperative serum CA-125 levels were 75% sensitivity, 75% specificity, 39.5% positive predictive value, 93.2% negative predictive value, and 75% diagnostic
efficiency
for a
35U/ml cut-off and 55%, 89.1% 52.4%, 90.1%, and 83.0% respectively for a 65U/ml cut-off
These findings suggest that elevated serum CA0125 levels help differential diagnosis of @EN ovarian malignancy from benign ovarian tumor preoperatively. The serum CA0125 levels seem to provide less information for early diagnosis of malignant
ovarian
tumors due to false negativity of early stage in ovarian malignancy but preoperative CA0125 levels have good correlation with clinical stage of ovarian malignancy. Accurate diagnosis of the malignant ovarian tumors may be difficult because pelvic
abscess showed especially high concentrations and false positive rate of preoperative serum CA0125, therefore further evaluations of CA0125 levels in pelvic pelvic abscess in needed.
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